Mol Cancer. 2007 Jun 4;6:35.

t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia.

Liu D, Shimonov J, Primanneni S, Lai Y, Ahmed T, Seiter K.

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Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA. delong_liu@nymc.edu

Abstract

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.

PMID:: 17547754; [PubMed - indexed for MEDLINE]
PMCID: PMC1904237

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