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Br J Psychiatry. 2007 Jun;190:460-6.

Effects of antidepressant treatment following myocardial infarction.

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  • 1Department of Cardiology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, The Netherlands.

Abstract

BACKGROUND:

Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis.

AIMS:

To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study.

METHOD:

In a multicentre randomised controlled trial, 2177 myocardial infarction patients were evaluated for ICD-10 depression and randomised to intervention (n=209) or care as usual (n=122). Both arms were evaluated at 18 months post-myocardial infarction for long-term depression status and new cardiac events.

RESULTS:

No differences were observed between intervention and control groups in mean scores on the Beck Depression Inventory (11.0, s.d.=7.5 v.10.2, s.d.=5.1, P=0.45) or presence of ICD-10 depression (30.5 v. 32.1%, P=0.68). The cardiac event rate was 14% among the intervention group and 13% among controls (OR=1.07, 95% CI 0.57-2.00).

CONCLUSIONS:

Antidepressant treatment did not alter long-term depression post-myocardial infarction status or improve cardiac prognosis.

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