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J Cell Biol. 2007 Jun 4;177(5):751-5. Epub 2007 May 29.

Building blood vessels--stem cell models in vascular biology.

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  • 1Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.


Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.

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