OBJECTIVES: To describe hand function among patients with multiple sclerosis (MS) and to examine the relationship between strength and self-reported abilities. DESIGN: Cross-sectional study using a convenience sample. SETTING: Outpatient department at a rehabilitation center. PARTICIPANTS: Forty-four community-dwelling adults with MS (mean age, 49+/-9 y; range, 34-68 y) who were monitored by rehabilitation practitioners. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Grip and pinch (tip, lateral, palmar) strengths and Manual Ability Measure (MAM-36). RESULTS: When compared with the 50- to 54-year-old female norms, the pinch and grip strengths of the sample were lower. MAM-36 correlated moderately with right pinch (tip, lateral, palmar) strengths (r range, .51-.59; P<.01). CONCLUSIONS: Manual ability seems to be more associated with pinch than grip strengths, probably because finger strength and dexterity are both needed to perform many hand tasks.