FEBS Lett. 2007 Jun 19;581(15):2829-38. Epub 2007 May 21.

Legionella pneumophila adaptation to intracellular life and the host response: clues from genomics and transcriptomics.

Source

Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Institut Pasteur, 25-28 Rue du Dr. Roux, 75724 Paris Cedex 15, France.

Abstract

Legionella pneumophila is the causative agent of the pneumonia-like Legionnaires' disease. The bacterium's survival and spread depend on the ability to replicate inside eukaryotic phagocytic cells. A particular feature of Legionella is its dual host system allowing the intracellular growth in protozoa like Acanthamoeba castellanii, and during infection in human alveolar macrophages. Genome analysis and comparisons as well as expression profiling of the pathogen and the host helped to identify regulatory circuits mediating adaptation of the L. pneumophila transcriptome to the intracellular environment and gave clues for the metabolic needs of intracellular Legionella. This review will summarize what is currently known about intracellular gene expression of L. pneumophila, the transcriptional host response of the model host Dictyostelium discoideum and will present hypotheses drawn from these data with respect to subversion of host cell functions and virulence of L. pneumophila.

PMID:: 17531986; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila. [Cell Microbiol. 2006]
Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila.
Brüggemann H, Hagman A, Jules M, Sismeiro O, Dillies MA, Gouyette C, Kunst F, Steinert M, Heuner K, Coppée JY, et al. Cell Microbiol. 2006 Aug; 8(8):1228-40.
Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease. [PLoS Genet. 2010]
Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease.
Cazalet C, Gomez-Valero L, Rusniok C, Lomma M, Dervins-Ravault D, Newton HJ, Sansom FM, Jarraud S, Zidane N, Ma L, et al. PLoS Genet. 2010 Feb 19; 6(2):e1000851. Epub 2010 Feb 19.
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA. [Cell Microbiol. 2007]
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.
Tiaden A, Spirig T, Weber SS, Brüggemann H, Bosshard R, Buchrieser C, Hilbi H. Cell Microbiol. 2007 Dec; 9(12):2903-20. Epub 2007 Jul 5.
Review Legionella pathogenicity: genome structure, regulatory networks and the host cell response. [Int J Med Microbiol. 2007]
Review Legionella pathogenicity: genome structure, regulatory networks and the host cell response.
Steinert M, Heuner K, Buchrieser C, Albert-Weissenberger C, Glöckner G. Int J Med Microbiol. 2007 Nov; 297(7-8):577-87. Epub 2007 Apr 30.
Review Adaptation of Legionella pneumophila to the host environment: role of protein secretion, effectors and eukaryotic-like proteins. [Curr Opin Microbiol. 2006]
Review Adaptation of Legionella pneumophila to the host environment: role of protein secretion, effectors and eukaryotic-like proteins.
Brüggemann H, Cazalet C, Buchrieser C. Curr Opin Microbiol. 2006 Feb; 9(1):86-94. Epub 2006 Jan 6.

See reviews... See all...

Cited by 11 PubMed Central articles

Effector glycosyltransferases in legionella. [Front Microbiol. 2011]
Effector glycosyltransferases in legionella.
Belyi Y, Jank T, Aktories K. Front Microbiol. 2011; 2:76. Epub 2011 Apr 12.
Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages. [Front Microbiol. 2011]
Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages.
Faucher SP, Mueller CA, Shuman HA. Front Microbiol. 2011; 2:60. Epub 2011 Apr 4.
Sequencing illustrates the transcriptional response of Legionella pneumophila during infection and identifies seventy novel small non-coding RNAs. [PLoS One. 2011]
Sequencing illustrates the transcriptional response of Legionella pneumophila during infection and identifies seventy novel small non-coding RNAs.
Weissenmayer BA, Prendergast JG, Lohan AJ, Loftus BJ. PLoS One. 2011 Mar 3; 6(3):e17570. Epub 2011 Mar 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Legionella pneumophila adaptation to intracellular life and the host response: c...
Legionella pneumophila adaptation to intracellular life and the host response: clues from genomics and transcriptomics.
FEBS Lett. 2007 Jun 19 ;581(15):2829-38. Epub 2007 May 21 .

PubMed
Cardiorespiratory fitness and risk of nonfatal cardiovascular disease in women a...
Cardiorespiratory fitness and risk of nonfatal cardiovascular disease in women and men with hypertension.
Am J Hypertens. 2007 Jun ;20(6):608-15.

PubMed
Risks associated with drug-eluting stents.
Risks associated with drug-eluting stents.
Lancet. 2007 May 26 ;369(9575):1785; author reply 1785-6.

PubMed
Sexual and reproductive health services and HIV testing: perspectives and experi...
Sexual and reproductive health services and HIV testing: perspectives and experiences of women and men living with HIV and AIDS.
Reprod Health Matters. 2007 May ;15(29 Suppl):113-35.

PubMed
Association of multiple inflammatory markers with carotid intimal medial thickne...
Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).
Am J Cardiol. 2007 Jun 1 ;99(11):1598-602. Epub 2007 Apr 18 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Legionella pneumophila adaptation to intracellular life and the host response: clues from genomics and transcriptomics.

Source

Abstract

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information