Pneumatosis intestinalis and portal venous gas without bowel ischemia in a patient treated with irinotecan and cisplatin

Dig Dis Sci. 2008 Jan;53(1):217-9. doi: 10.1007/s10620-007-9846-9. Epub 2007 May 26.

Abstract

Pneumatosis intestinalis and gas within the portal venous system are findings predictive of bowel ischemia. The etiologies of these alarming radiographic signs are diverse and not all causes require emergent surgical intervention. The combination of pneumatosis intestinalis, portal venous gas, and acidosis typically portends bowel ischemia and inevitable necrosis. This case report is the first description of benign pneumatosis and portal venous gas secondary to irinotecan and cisplatin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Camptothecin / adverse effects
  • Camptothecin / analogs & derivatives*
  • Camptothecin / therapeutic use
  • Cisplatin / adverse effects*
  • Cisplatin / therapeutic use
  • Colon / blood supply
  • Diagnosis, Differential
  • Embolism, Air / chemically induced*
  • Embolism, Air / diagnostic imaging
  • Esophageal Neoplasms / drug therapy
  • Follow-Up Studies
  • Humans
  • Intestine, Small / blood supply
  • Irinotecan
  • Ischemia / diagnosis*
  • Ischemia / surgery
  • Laparotomy
  • Male
  • Pneumatosis Cystoides Intestinalis / chemically induced*
  • Pneumatosis Cystoides Intestinalis / diagnostic imaging
  • Portal Vein*
  • Prodrugs
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents
  • Prodrugs
  • Irinotecan
  • Cisplatin
  • Camptothecin