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Nat Genet. 2007 Jun;39(6):730-2. Epub 2007 May 21.

Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

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  • 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Abstract

We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.

PMID:
17529977
[PubMed - indexed for MEDLINE]
PMCID:
PMC3797512
Free PMC Article

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