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Pediatr Infect Dis J. 2007 Jun;26(6):542-4.

Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy.

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  • 1Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan. ichiyama@yamaguchi-u.ac.jp

Abstract

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.

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