GeneTrail--advanced gene set enrichment analysis

Nucleic Acids Res. 2007 Jul;35(Web Server issue):W186-92. doi: 10.1093/nar/gkm323. Epub 2007 May 25.

Abstract

We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representation Analysis' (ORA) comparing a reference set of genes to a test set, and 'Gene Set Enrichment Analysis' (GSEA) scoring sorted lists of genes. Besides other newly developed features, GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably. GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Database Management Systems
  • Databases, Genetic
  • Gene Expression Regulation*
  • Genes, Fungal
  • Genome
  • Genomics*
  • Humans
  • Internet
  • Models, Genetic
  • Models, Statistical
  • Programming Languages
  • Proteomics*
  • Software
  • User-Computer Interface