J Public Health (Oxf). 2007 Sep;29(3):246-50. Epub 2007 May 24.

The evaluation of genetic tests.

Source

Public Health Genetics Unit, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.

Abstract

Scientific advances in genetics and molecular biology have been very successful in advancing our knowledge of biological mechanisms in health and disease, and in catalysing a variety of technological innovations. The number of genetic tests available has consequently increased exponentially over the last few years. Their development has not been accompanied by processes and systems to evaluate these tests in a proper and formal manner to establish their clinical validity and utility. A framework for the evaluation of genetic tests has been developed. This paper reviews the current practice of genetic test evaluation, highlighting the limitations and future challenges in this area of public health.

PMID:: 17526507; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Genetic Markers

LinkOut - more resources

Full Text Sources

Medical

Genetic Testing - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Clinical validity and clinical utility of genetic tests. [Curr Protoc Hum Genet. 2009]
Clinical validity and clinical utility of genetic tests.
Burke W. Curr Protoc Hum Genet. 2009 Jan; Chapter 9:Unit 9.15.
Review Ethical and clinical practice considerations for genetic counselors related to direct-to-consumer marketing of genetic tests. [Am J Med Genet C Semin Med Gen...]
Review Ethical and clinical practice considerations for genetic counselors related to direct-to-consumer marketing of genetic tests.
Wade CH, Wilfond BS. Am J Med Genet C Semin Med Genet. 2006 Nov 15; 142C(4):284-92, discussion 293.
Review Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests. [J Nutrigenet Nutrigenomics. 2008]
Review Public health genomics and genetic test evaluation: the challenge of conducting behavioural research on the utility of lifestyle-genetic tests.
Sanderson SC, Wardle J, Humphries SE. J Nutrigenet Nutrigenomics. 2008; 1(5):224-31. Epub 2008 Aug 6.
Review Genetic test evaluation: information needs of clinicians, policy makers, and the public. [Am J Epidemiol. 2002]
Review Genetic test evaluation: information needs of clinicians, policy makers, and the public.
Burke W, Atkins D, Gwinn M, Guttmacher A, Haddow J, Lau J, Palomaki G, Press N, Richards CS, Wideroff L, et al. Am J Epidemiol. 2002 Aug 15; 156(4):311-8.
Review Genetic epidemiology and public health: hope, hype, and future prospects. [Lancet. 2005]
Review Genetic epidemiology and public health: hope, hype, and future prospects.
Davey Smith G, Ebrahim S, Lewis S, Hansell AL, Palmer LJ, Burton PR. Lancet. 2005 Oct 22-28; 366(9495):1484-98.

See reviews... See all...

Cited by 1 PubMed Central article

Debating clinical utility. [Public Health Genomics. 2010]
Debating clinical utility.
Burke W, Laberge AM, Press N. Public Health Genomics. 2010; 13(4):215-23. Epub 2010 Apr 15.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The evaluation of genetic tests.
The evaluation of genetic tests.
J Public Health (Oxf). 2007 Sep ;29(3):246-50. Epub 2007 May 24 .

PubMed
Transcriptional regulation of the bovine leukemia virus promoter by the cyclic A...
Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator tau isoform.
J Biol Chem. 2007 Jul 20 ;282(29):20854-67. Epub 2007 May 25 .

PubMed
Who will care for the grandparents? Exploring relationships between grandparents...
Who will care for the grandparents? Exploring relationships between grandparents and grandchildren.
J Psychosoc Nurs Ment Health Serv. 2007 May ;45(5):19-22.

PubMed
The origin and virulence of the 1918 "Spanish" influenza virus.
The origin and virulence of the 1918 "Spanish" influenza virus.
Proc Am Philos Soc. 2006 Mar ;150(1):86-112.

PubMed
Effects of a mutation in the Drosophila porin gene encoding mitochondrial voltag...
Effects of a mutation in the Drosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction.
Dev Neurobiol. 2007 Sep 15 ;67(11):1533-45.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: