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Intensive Care Med. 2007 Aug;33(8):1347-53. Epub 2007 May 25.

High-mobility group box 1 protein plasma concentrations during septic shock.

Author information

  • 1Hôpital Central, Service de Réanimation Médicale, 29 avenue du Maréchal de Lattre de Tassigny, 54000, Nancy, France. s.gibot@chu-nancy.fr

Abstract

OBJECTIVE:

To investigate plasma high-mobility group box 1 protein (HMGB1) concentration and its relationship with organ dysfunction and outcome in septic shock patients.

DESIGN AND SETTING:

Prospective, noninterventional study. Medical adult intensive care unit at a university hospital in France.

PATIENTS:

42 critically ill patients with septic shock.

METHODS:

Arterial blood was drawn within 12 h of admission for the measurement of plasma HMGB1 concentration by ELISA. Repeated sampling was performed on days 3, 7, and 14.

RESULTS:

Median HMGB1 concentration was 4.4 ng/ml (IQR 1.2-12.5) at admission, with no difference between survivors and nonsurvivors. A positive correlation was observed between HMGB1 and SOFA score and lactate, and procalcitonin concentrations. There was a progressive but statistically nonsignificant decline in HMGB1 concentration among the survivors, while nonsurvivors showed an increase in HMGB1 level between days 1 and 3. SOFA score and lactate and procalcitonin concentrations did not vary significantly between days 1 and 3. When measured on day 3, HMGB1 discriminated survivors from nonsurvivors with 66% sensitivity and 67% specificity, and concentration greater than 4 ng/ml was associated with an odds ratio of death of 5.5 (95% CI 1.3-23.6).

PMID:
17525840
[PubMed - indexed for MEDLINE]
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