Schizophr Res. 2007 Aug;94(1-3):1-11. Epub 2007 May 23.

Neurotrophins and schizophrenia.

Buckley PF, Mahadik S, Pillai A, Terry A Jr.

Source

Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States. pbuckley@mail.mcg.edu

Abstract

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

PMID:: 17524622; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Schizophrenia - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review [New pharmacological approaches to the treatment of schizophrenia]. [Turk Psikiyatri Derg. 2009]
Review [New pharmacological approaches to the treatment of schizophrenia].
Uzbay IT. Turk Psikiyatri Derg. 2009 Summer; 20(2):175-82.
Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and schwann cells in vitro. [Brain Res. 2000]
Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and schwann cells in vitro.
Alderson RF, Curtis R, Alterman AL, Lindsay RM, DiStefano PS. Brain Res. 2000 Jul 21; 871(2):210-22.
Review The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. [Eur Neuropsychopharmacol. 2005]
Review The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia.
Shoval G, Weizman A. Eur Neuropsychopharmacol. 2005 May; 15(3):319-29.
Review Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia. [Prog Brain Res. 2004]
Review Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia.
Angelucci F, Mathé AA, Aloe L. Prog Brain Res. 2004; 146:151-65.
Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. [J Neurosci Res. 2000]
Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration.
Angelucci F, Mathé AA, Aloe L. J Neurosci Res. 2000 Jun 15; 60(6):783-94.

See reviews... See all...

Cited by 15 PubMed Central articles

Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients. [PLoS One. 2012]
Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients.
van Beveren NJ, Buitendijk GH, Swagemakers S, Krab LC, Röder C, de Haan L, van der Spek P, Elgersma Y. PLoS One. 2012; 7(2):e32618. Epub 2012 Feb 29.
Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse. [Eur J Histochem. 2009]
Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse.
Imura K, Sato I. Eur J Histochem. 2009 Dec 29; 53(4):e27.
Brain-derived neurotrophic factor in patients with Huntington's disease. [PLoS One. 2011]
Brain-derived neurotrophic factor in patients with Huntington's disease.
Zuccato C, Marullo M, Vitali B, Tarditi A, Mariotti C, Valenza M, Lahiri N, Wild EJ, Sassone J, Ciammola A, et al. PLoS One. 2011; 6(8):e22966. Epub 2011 Aug 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Neurotrophins and schizophrenia.
Neurotrophins and schizophrenia.
Schizophr Res. 2007 Aug ;94(1-3):1-11. Epub 2007 May 23 .

PubMed
Fat necrosis after partial-breast irradiation with brachytherapy or electron irr...
Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy--4-year results of a randomized trial.
Int J Radiat Oncol Biol Phys. 2007 Nov 1 ;69(3):724-31. Epub 2007 May 24 .

PubMed
Expression and characterization of a novel reverse transcriptase of the LTR retr...
Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1.
Virology. 2007 Sep 30 ;366(2):263-76. Epub 2007 May 23 .

PubMed
Obesity by choice revisited: effects of food availability, flavor variety and nu...
Obesity by choice revisited: effects of food availability, flavor variety and nutrient composition on energy intake.
Physiol Behav. 2007 Oct 22 ;92(3):468-78. Epub 2007 Apr 24 .

PubMed
Solid-state NMR as a method to reveal structure and membrane-interaction of amyl...
Solid-state NMR as a method to reveal structure and membrane-interaction of amyloidogenic proteins and peptides.
Biochim Biophys Acta. 2007 Aug ;1768(8):1900-12. Epub 2007 Apr 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Neurotrophins and schizophrenia.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 15 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information