Neurotrophins and schizophrenia. [Schizophr Res. 2007]

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1: Schizophr Res. 2007 Aug;94(1-3):1-11. Epub 2007 May 23. Links

Neurotrophins and schizophrenia.

Buckley PF, Mahadik S, Pillai A, Terry A Jr.

Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States. pbuckley@mail.mcg.edu

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

PMID: 17524622 [PubMed - indexed for MEDLINE]

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Neurotrophins and schizophrenia.

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