Neurotrophins and schizophrenia. [Schizophr Res. 2007]

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1: Schizophr Res. 2007 Aug;94(1-3):1-11. Epub 2007 May 23. Links

Neurotrophins and schizophrenia.

Buckley PF, Mahadik S, Pillai A, Terry A Jr.

Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States. pbuckley@mail.mcg.edu

Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.

PMID: 17524622 [PubMed - indexed for MEDLINE]

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ReviewBDNF in schizophrenia, depression and corresponding animal models.
Mol Psychiatry. 2005 Apr; 10(4):345-52.

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ReviewBrain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia.
Neurosignals. 2008; 16(2-3):183-93. Epub 2008 Feb 5.

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Effects of the Chinese traditional prescription Xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats.
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Cited by 3 PubMed Central articles

Role of the central cholinergic system in the therapeutics of schizophrenia.
Terry AV Jr. Curr Neuropharmacol. 2008 Sep; 6(3):286-92.

[Curr Neuropharmacol. 2008]
ReviewGlutamate and neurotrophic factors in neuronal plasticity and disease.
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[Ann N Y Acad Sci. 2008]
Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression.
Pillai A. PLoS One. 2008 Mar 12; 3(3):e1784. Epub 2008 Mar 12.

[PLoS One. 2008]

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