Incidence and etiologic structure of shigellosis in Karachaevo-Cherkes Republic for 10 years are analyzed and compared with same characteristics in Russia overall. Sharp rise of shigellosis cases number is detected in 2003-2005 as well as predominance of Shigella sonnei represented by biovar Ilg. It was shown that Shigella strains with different resistance to tetracycline and chloramphenicol circulate in Karachaevo-Cherkes Republic.