Hodgkin's lymphoma in a patient with Jo-1 syndrome.

Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. alexander.adam@ukb.uni-bonn.de

Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin's lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.

PMID: 17522890 [PubMed - indexed for MEDLINE]