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Eur J Clin Nutr. 2008 Jul;62(7):908-15. Epub 2007 May 16.

Prospective study of coffee consumption and risk of Parkinson's disease.

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  • 1National Public Health Institute, Mannerheimintie 166, Helsinki, Finland.

Abstract

OBJECTIVE:

To examine the prediction of coffee consumption on the incidence of Parkinson's disease.

SUBJECTS AND METHODS:

The study population comprised 6710 men and women, aged 50-79 years and free from Parkinson's disease at the baseline. At baseline, enquiries were made about coffee consumption in a self-administered questionnaire as the average number of cups per day. During a 22-year follow-up, 101 incident cases of Parkinson's disease occurred. Parkinson's disease cases were identified through a nationwide registry of patients receiving medication reimbursement, which is based on certificates from neurologist.

RESULTS:

After adjustments for age, sex, marital status, education, community density, alcohol consumption, leisure-time physical activity, smoking, body mass index, hypertension and serum cholesterol, the relative risk for subjects drinking 10 or more cups of coffee per day compared with non-drinkers was 0.26 (95% confidence interval 0.07-0.99, P-value for trend=0.18). The association was stronger among overweight persons and among persons with lower serum cholesterol level (P-value for interaction=0.04 and 0.03, respectively).

CONCLUSIONS:

The results support the hypothesis that coffee consumption reduces the risk of Parkinson's disease, but protective effect of coffee may vary by exposure to other factors.

PMID:
17522612
[PubMed - indexed for MEDLINE]
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