Format

Send to:

Choose Destination
See comment in PubMed Commons below
Fertil Steril. 2008 Jan;89(1):228.e19-22. Epub 2007 May 22.

In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation.

Author information

  • 1Department of Obstetrics and Gynecology, Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, New York 10021, USA. koktay@fertilitypreservation.org

Abstract

OBJECTIVE:

To report a novel approach to fertility preservation by in vitro maturation and embryo cryopreservation after LH surge and ovulation.

DESIGN:

Case report.

SETTING:

Two university-based reproductive endocrinology clinics.

PATIENT(S):

Forty-year-old woman with breast cancer seeking fertility preservation before chemotherapy.

INTERVENTION(S):

The plan was ovarian stimulation and retrieval of mature oocytes, followed by IVF; however, premature LH surge and ovulation occurred before oocyte retrieval. Because no mature oocyte was recovered, follicles <10 mm in diameter were also aspirated.

MAIN OUTCOME MEASURE(S):

Recovery of immature oocytes after ovulation, in vitro maturation of these oocytes, and fertilization and vitrification of generated embryos.

RESULT(S):

Four immature oocytes were recovered, and two matured in vitro. After fertilization with intracytoplasmic sperm injection, embryos progressed to the four-cell stage on day 2 and were vitrified for future use.

CONCLUSION(S):

This case illustrates that under time constraints, immature oocytes can be recovered after ovulation and used to generate embryos for fertility preservation.

PMID:
17517403
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk