Autoimmunity. 2007 Jun;40(4):342-4.

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine.

Mueller RB, Sheriff A, Gaipl US, Wesselborg S, Lauber K.

Source

Department of Internal Medicine 3, Institute of Clinical Immunology and Rheumatology, University Hospital Erlangen, Erlangen, Germany. ruediger.muellr@gmx.org

Abstract

Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearance of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.

PMID:: 17516225; [PubMed - indexed for MEDLINE]

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Lysophosphatidylcholines

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