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J Bacteriol. 2007 Jul;189(14):5393-8. Epub 2007 May 18.

Requirement for YaeT in the outer membrane assembly of autotransporter proteins.

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  • 1Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Cambridge, MA 02139, USA.


Autotransporters constitute the largest group of secreted proteins in gram-negative bacteria. Autotransporter secretion involves the insertion of a carboxy-terminal beta barrel into and the translocation of an amino-terminal domain across the outer membrane. Here, we demonstrate that secretion of autotransporters from several organisms requires the outer membrane assembly factor YaeT.

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