Cell. 2007 May 18;129(4):787-99.

An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans.

Chuang CF, Vanhoven MK, Fetter RD, Verselis VK, Bargmann CI.

Source

Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Abstract

Gap junctions are widespread in immature neuronal circuits, but their functional significance is poorly understood. We show here that a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-right asymmetry in the developing nervous system of Caenorhabditis elegans. nsy-5 is required for the left and right AWC olfactory neurons to establish stochastic, asymmetric patterns of gene expression during embryogenesis. nsy-5-dependent gap junctions in the embryo transiently connect the AWC cell bodies with those of numerous other neurons. Both AWCs and several other classes of nsy-5-expressing neurons participate in signaling that coordinates left-right AWC asymmetry. The right AWC can respond to nsy-5 directly, but the left AWC requires nsy-5 function in multiple cells of the network. NSY-5 forms hemichannels and intercellular gap-junction channels in Xenopus oocytes, consistent with a combination of cell-intrinsic and network functions. These results provide insight into gap-junction activity in developing circuits.

Comment in

Cell. 2007 May 18;129(4):645-7.

PMID:: 17512411; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Grant Support

R01 DC04089/DC/NIDCD NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. [Neural Dev. 2007]
Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans.
Bauer Huang SL, Saheki Y, VanHoven MK, Torayama I, Ishihara T, Katsura I, van der Linden A, Sengupta P, Bargmann CI. Neural Dev. 2007 Nov 6; 2:24. Epub 2007 Nov 6.
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans. [Genes Dev. 2009]
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans.
Lesch BJ, Gehrke AR, Bulyk ML, Bargmann CI. Genes Dev. 2009 Feb 1; 23(3):345-58.
The claudin superfamily protein nsy-4 biases lateral signaling to generate left-right asymmetry in C. elegans olfactory neurons. [Neuron. 2006]
The claudin superfamily protein nsy-4 biases lateral signaling to generate left-right asymmetry in C. elegans olfactory neurons.
Vanhoven MK, Bauer Huang SL, Albin SD, Bargmann CI. Neuron. 2006 Aug 3; 51(3):291-302.
Review Gap junctions provide new links in left-right patterning. [Cell. 2007]
Review Gap junctions provide new links in left-right patterning.
Oviedo NJ, Levin M. Cell. 2007 May 18; 129(4):645-7.
Review Innexins: members of an evolutionarily conserved family of gap-junction proteins. [Biochim Biophys Acta. 2005]
Review Innexins: members of an evolutionarily conserved family of gap-junction proteins.
Phelan P. Biochim Biophys Acta. 2005 Jun 10; 1711(2):225-45. Epub 2004 Nov 17.

See reviews... See all...

Cited by 20 PubMed Central articles

Low frequency vibrations disrupt left-right patterning in the Xenopus embryo. [PLoS One. 2011]
Low frequency vibrations disrupt left-right patterning in the Xenopus embryo.
Vandenberg LN, Pennarola BW, Levin M. PLoS One. 2011; 6(8):e23306. Epub 2011 Aug 3.
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans. [Development. 2011]
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans.
Chang C, Hsieh YW, Lesch BJ, Bargmann CI, Chuang CF. Development. 2011 Aug; 138(16):3509-18. Epub 2011 Jul 19.
A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. [Mol Brain. 2011]
A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel.
Bouhours M, Po MD, Gao S, Hung W, Li H, Georgiou J, Roder JC, Zhen M. Mol Brain. 2011 Apr 13; 4:16. Epub 2011 Apr 13.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

An innexin-dependent cell network establishes left-right neuronal asymmetry in C...
An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans.
Cell. 2007 May 18 ;129(4):787-99.

PubMed
Male circumcision for HIV prevention: research implications for policy and progr...
Male circumcision for HIV prevention: research implications for policy and programming. WHO/UNAIDS technical consultation, 6-8 March 2007. Conclusions and recommendations (excerpts).
Reprod Health Matters. 2007 May ;15(29):11-4.

PubMed
Plasma concentrations of myeloperoxidase predict mortality after myocardial infa...
Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction.
J Am Coll Cardiol. 2007 May 22 ;49(20):1993-2000. Epub 2007 May 4 .

PubMed
Phase 1A safety assessment of intravenous amitriptyline.
Phase 1A safety assessment of intravenous amitriptyline.
J Pain. 2007 Jul ;8(7):549-55. Epub 2007 May 23 .

PubMed
Changes in expression of cell wall turnover genes accompany inhibition of chromo...
Changes in expression of cell wall turnover genes accompany inhibition of chromosome segregation by bovine protein kinase C alpha expression in Saccharomyces cerevisiae.
Cell Biol Int. 2007 Oct ;31(10):1160-72. Epub 2007 Mar 31 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: