FEBS Lett. 2007 Jun 19;581(15):2783-93. Epub 2007 May 11.

Nuclear export and cytoplasmic maturation of ribosomal subunits.

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Institute of Biochemistry, HPM F11.1, Schafmattstr. 18, ETH Zurich, 8093 Zurich, Switzerland.

Abstract

Based on the characterization of ribosome precursor particles and associated trans-acting factors, a biogenesis pathway for the 40S and 60S subunits has emerged. After nuclear synthesis and assembly steps, pre-ribosomal subunits are exported through the nuclear pore complex in a Crm1- and RanGTP-dependent manner. Subsequent cytoplasmic biogenesis steps of pre-60S particles include the facilitated release of several non-ribosomal proteins, yielding fully functional 60S subunits. Cytoplasmic maturation of 40S subunit precursors includes rRNA dimethylation and pre-rRNA cleavage, allowing 40S subunits to achieve translation competence. We review current knowledge of nuclear export and cytoplasmic maturation of ribosomal subunits.

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Nuclear export and cytoplasmic maturation of ribosomal subunits.

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