Epilepsia. 2007 May;48(5):1015-8.

Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.

Man CB, Kwan P, Baum L, Yu E, Lau KM, Cheng AS, Ng MH.

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Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.

Erratum in

Epilepsia. 2008 May;49(5):941.

Abstract

A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED-tolerant controls. HLA-B*1502 was associated with severe cutaneous reactions (SCR) induced by AEDs, which included carbamazepine, phenytoin, and lamotrigine (p = 0.001, odds ratio = 17.6), but was not associated with maculopapular exanthema (MPE) (p = 0.32). Further studies in larger samples of ethnically matched subjects should be conducted to confirm the findings. Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals.

Comment in

Of race, ethnicity, and rash: the genetics of antiepileptic drug-induced skin reactions. [Epilepsy Curr. 2008]
Of race, ethnicity, and rash: the genetics of antiepileptic drug-induced skin reactions.Miller JW. Epilepsy Curr. 2008 Sep-Oct; 8(5):120-1.
HLA-B*1502 allele screening: determination of carbamazepine-induced cutaneous reactions. [Epilepsia. 2012]
HLA-B*1502 allele screening: determination of carbamazepine-induced cutaneous reactions.Wu Y, Wang XQ, Gan ZJ, Fan M. Epilepsia. 2012 May; 53(5):929-30.

PMID:: 17509004; [PubMed - indexed for MEDLINE]

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