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    Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):892-4.

    Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

    Daley D, Morgan W, Lewis S, Willis J, Elston RC, Markowitz SD, Wiesner GL.

    Department of Epidemiology, University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio, USA. ddaley@mrl.ubc.ca

    Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.

    PMID: 17507611 [PubMed - indexed for MEDLINE]

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