Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Crawford H,
Prado JG,
Leslie A,
Hué S,
Honeyborne I,
Reddy S,
van der Stok M,
Mncube Z,
Brander C,
Rousseau C,
Mullins JI,
Kaslow R,
Goepfert P,
Allen S,
Hunter E,
Mulenga J,
Kiepiela P,
Walker BD,
Goulder PJ.
Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd., Oxford OX1 3SY, United Kingdom.
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
PMID: 17507468 [PubMed - indexed for MEDLINE]
PMCID: PMC1951305