Send to:

Choose Destination
See comment in PubMed Commons below
Biochem Biophys Res Commun. 2007 Jul 6;358(3):777-82. Epub 2007 May 8.

A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation.

Author information

  • 1Karolinska Institutet, Department of Neurobiology, Caring Sciences and Society, Novum, 141 86 Stockholm, Sweden.


In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular Abeta staining. The Abeta is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PS1 transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk