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    Biochem Biophys Res Commun. 2007 Jul 6;358(3):873-8. Epub 2007 May 8.

    A fused selenium-containing protein with both GPx and SOD activities.

    Yu H, Ge Y, Wang Y, Lin CT, Li J, Liu X, Zang T, Xu J, Liu J, Luo G, Shen J.

    Source

    Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, People's Republic of China.

    Abstract

    As a safeguard against oxidative stress, the balance between the main antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) was believed to be more important than any single one, for example, dual-functional SOD/CAT enzyme has been proved to have better antioxidant ability than either single enzyme. By combining traditional fusion protein technology with amino acid auxotrophic expression system, we generated a bifunctional enzyme with both GPx and SOD activities. It displayed better antioxidant ability than GPx or SOD. Such dual-functional enzymes could facilitate further studies of the cooperation of GPx and SOD and generation of better therapeutic agents.

    PMID:
    17506982
    [PubMed - indexed for MEDLINE]

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