Send to:

Choose Destination
See comment in PubMed Commons below
Annu Rev Neurosci. 2007;30:153-79.

Why is Wallerian degeneration in the CNS so slow?

Author information

  • 1Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA.


Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery. Here we review current work on the mechanisms of WD with an emphasis on deciphering this mystery and on understanding whether slow WD in the CNS could account for the failure of CNS axons to regenerate.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk