Anaesthesia. 1991 Nov;46(11):973-6.

Inhaled nebulised fentanyl for postoperative analgesia.

Source

Department of Anaesthesia, Southern General Hospital, Glasgow.

Abstract

The effects of three concentrations of inhaled nebulised fentanyl citrate solution given for postoperative pain relief were studied. Each of 30 patients inhaled one dose of 3 ml of solution nebulised over 9 min. A combined analysis of pain relief, time to further analgesia and effect on respiratory frequency showed the highest concentration (318 micrograms/ml fentanyl base) to be more effective (p less than 0.01) than the two lower concentrations (159 micrograms/ml and 64 micrograms/ml) which were indistinguishable from each other. There were no major side effects. This study provides evidence for the efficacy and safety of inhaled fentanyl for postoperative analgesia. Estimation of the delivered doses did not support the hypothesis that fentanyl is more effective by this route compared with other parenteral routes. Further studies are required to improve the method of delivery and investigate the pharmacodynamic features of this technique.

PMID:: 1750604; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Fentanyl

LinkOut - more resources

Full Text Sources

Swets Information Services

Education

Medical

Pain - MedlinePlus Health Information

Molecular Biology Databases

FENTANYL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Inhaled fentanyl as a method of analgesia. [Anaesthesia. 1990]
Inhaled fentanyl as a method of analgesia.
Worsley MH, MacLeod AD, Brodie MJ, Asbury AJ, Clark C. Anaesthesia. 1990 Jun; 45(6):449-51.
The minimally effective concentration of adrenaline in a low-concentration thoracic epidural analgesic infusion of bupivacaine, fentanyl and adrenaline after major surgery. A randomized, double-blind, dose-finding study. [Acta Anaesthesiol Scand. 2003]
The minimally effective concentration of adrenaline in a low-concentration thoracic epidural analgesic infusion of bupivacaine, fentanyl and adrenaline after major surgery. A randomized, double-blind, dose-finding study.
Niemi G, Breivik H. Acta Anaesthesiol Scand. 2003 Apr; 47(4):439-50.
Minimum effective combination dose of epidural morphine and fentanyl for posthysterectomy analgesia: a randomized, prospective, double-blind study. [Anesth Analg. 1993]
Minimum effective combination dose of epidural morphine and fentanyl for posthysterectomy analgesia: a randomized, prospective, double-blind study.
Tanaka M, Watanabe S, Ashimura H, Akiyoshi Y, Nishijima Y, Sato S, Naito H. Anesth Analg. 1993 Nov; 77(5):942-6.
Postoperative analgesic effects of three demand-dose sizes of fentanyl administered by patient-controlled analgesia. [Anesth Analg. 1998]
Postoperative analgesic effects of three demand-dose sizes of fentanyl administered by patient-controlled analgesia.
Camu F, Van Aken H, Bovill JG. Anesth Analg. 1998 Oct; 87(4):890-5.
Continuous administration of fentanyl for postoperative pain: a comparison of the epidural, intravenous, and transdermal routes. [J Clin Anesth. 1994]
Continuous administration of fentanyl for postoperative pain: a comparison of the epidural, intravenous, and transdermal routes.
van Lersberghe C, Camu F, de Keersmaecker E, Sacré S. J Clin Anesth. 1994 Jul-Aug; 6(4):308-14.

See reviews... See all...

Cited by 2 PubMed Central articles

A review of transbuccal fentanyl use in the emergency department. [Pain Res Treat. 2012]
A review of transbuccal fentanyl use in the emergency department.
Arthur AO, Holder P. Pain Res Treat. 2012; 2012:768796. Epub 2012 Mar 20.
Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery. [Br J Clin Pharmacol. 1998]
Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery.
Mather LE, Woodhouse A, Ward ME, Farr SJ, Rubsamen RA, Eltherington LG. Br J Clin Pharmacol. 1998 Jul; 46(1):37-43.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Inhaled nebulised fentanyl for postoperative analgesia.
Inhaled nebulised fentanyl for postoperative analgesia.
Anaesthesia. 1991 Nov ;46(11):973-6.

PubMed
Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis...
Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis.
Eur Cell Mater. 2007 May 15 ;13:76-86.

PubMed
Etiology of three recent diseases of citrus in São Paulo State: sudden death, va...
Etiology of three recent diseases of citrus in São Paulo State: sudden death, variegated chlorosis and huanglongbing.
IUBMB Life. 2007 Apr-May ;59(4-5):346-54.

PubMed
The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present i...
The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma.
Braz J Otorhinolaryngol. 2007 Jan-Feb ;73(1):117-21.

PubMed
Personalized medicine: elusive dream or imminent reality?
Personalized medicine: elusive dream or imminent reality?
Clin Pharmacol Ther. 2007 Jun ;81(6):807-16.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: