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Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Mar;75(3 Pt 1):031917. Epub 2007 Mar 30.

Stochastic suppression of gene expression oscillators under intercell coupling.

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  • 1Institut für Physik, Potsdam Universität, Am Neuen Palais 10, D-14469 Potsdam, Germany.


This paper examines the dynamics of an ensemble of hysteresis-based genetic relaxation oscillators, focusing on the influence of noise and cell-to-cell coupling on the appearance of new dynamical regimes. In particular, we show that control of the coupling strength and noise can effectively change the dynamics of the system leading to behaviors such as clustering, synchronous and asynchronous oscillations, and suppression. Moreover, under certain conditions an optimal amount of noise can lead to increased order in the system. The results obtained are correlated with relevant biological processes that occur in living organisms.

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