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Pathol Res Pract. 2007;203(6):485-7. Epub 2007 May 10.

A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.

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  • 1Department of Experimental Biology, Faculty of Sciences, University of Jaén, Paraje de las Lagunillas s/n 23071, Jaén, Spain.


In the present study, we investigate intestinal alkaline phosphatase activity in mucosal biopsies in patients with inflammatory bowel disease. Crohn's disease influences the alkaline phosphatase activity in the intestine, increasing its activity. We present a histochemistry-based method for alkaline phosphatase that is useful for the identification of Crohn's disease and the differentiation of ulcerative colitis.

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