Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Mol Cell Cardiol. 2007 Jun;42(6):1137-41. Epub 2007 Apr 14.

Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy.

Author information

  • 1Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

MicroRNAs (miRNAs) are a recently discovered class of approximately 22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and miR-133 play an important role in modulating muscle proliferation and differentiation. Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in pressure overload-induced hypertrophic hearts and found the miRNA expression profile altered in those hypertrophic conditions. We further show that inhibition of endogenous miR-21 or miR-18b augments hypertrophic growth. Conversely, introduction of functional miR-21 or miR-18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy.

PMID:
17498736
[PubMed - indexed for MEDLINE]
PMCID:
PMC1934409
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk