Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb

Nat Prod Res. 2007 May 20;21(6):487-93. doi: 10.1080/14786410601012265.

Abstract

Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(-1), respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI(50) values of 6.1 and 0.9 microg mL(-1), respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC(50) values of 10.7 and 22.1 microg mL(-1), respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Proteins / antagonists & inhibitors*
  • Cell Line, Tumor
  • Colonic Neoplasms
  • Emodin / analogs & derivatives*
  • Emodin / chemistry
  • Emodin / isolation & purification
  • Emodin / pharmacology*
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Molecular Structure
  • Plant Roots / chemistry*
  • Polygonum / chemistry*
  • cdc25 Phosphatases / antagonists & inhibitors*

Substances

  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • questin
  • CDC25B protein, human
  • cdc25 Phosphatases
  • physcione
  • Emodin