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Nat Chem Biol. 2007 Jun;3(6):323-4. Epub 2007 May 13.

Diarylquinolines target subunit c of mycobacterial ATP synthase.

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  • 1Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@prdbe.jnj.com

Abstract

The diarylquinoline R207910 (TMC207) is a promising candidate in clinical development for the treatment of tuberculosis. Though R207910-resistant mycobacteria bear mutations in ATP synthase, the compound's precise target is not known. Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery.

PMID:
17496888
[PubMed - indexed for MEDLINE]
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