Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis

Autophagy. 2007 Sep-Oct;3(5):474-6. doi: 10.4161/auto.4341. Epub 2007 Apr 25.

Abstract

Animal models of cathepsin D (CD) deficiency are characterized by a progressive and relentless neurodegenerative phenotype similar to that observed in Neuronal Ceroid Lipofuscinoses (NCL), a group of pediatric neurodegenerative diseases known collectively as Batten Disease. We have shown recently that the targeted deletion of the pro-apoptotic molecule Bax prevents apoptotic markers but not neuron death and neurodegeneration induced by CD deficiency, which suggests that alterations in the macroautophagy-lysosomal degradation pathway can mediate neuron death in NCL/Batten Disease in the absence of apoptosis. Herein, we review CD deficiency in the broader context of NCL and offer potential mechanisms for neuron death and neurodegeneration induced by CD deficiency.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cathepsin D / deficiency*
  • Cathepsin D / genetics
  • Humans
  • Mutation
  • Nerve Degeneration / enzymology
  • Nerve Degeneration / genetics
  • Nerve Degeneration / pathology
  • Neuronal Ceroid-Lipofuscinoses / enzymology*
  • Neuronal Ceroid-Lipofuscinoses / genetics
  • Neuronal Ceroid-Lipofuscinoses / pathology*
  • Neurons / pathology

Substances

  • Cathepsin D