Nutr Rev. 1991 Oct;49(10):308-9.

The osteocalcin gene promoter: stimulated by vitamins A and D, inhibited by cell-growth factors Jun-Fos.

[No authors listed]

Abstract

The gene of the bone protein osteocalcin has a promoter region recognized by the receptors for 1,25-dihydroxyvitamin D3 and retinoic acid, both of which stimulate transcription. Unexpectedly, this same gene element interacts with the cell-proliferation factors Jun-Fos, which inhibit osteocalcin gene transcription.

PMID:: 1749528; [PubMed - indexed for MEDLINE]

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