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1: Immunol Allergy Clin North Am. 2007 May;27(2):273-93, vii-viii.Click here to read Links

Idiopathic anaphylaxis.

Greenberger PA.

Division of Allergy-Immunology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 14018, 676 North St. Clair Street, Chicago, IL 60611, USA. p-greenberger@northwestern.edu

Idiopathic anaphylaxis is a prednisone-responsive condition without external cause, but it can coexist with food-, medication-, or exercise-induced anaphylaxis. Mast cell activation may occur at night or after foods that have been eaten with impunity many times previously. Idiopathic anaphylaxis can be classified into frequent (if there are six or more episodes per year or two episodes in the last 2 months) or infrequent (if episodes occur less often). Idiopathic anaphylaxis-generalized consists of urticaria or angioedema associated with severe respiratory distress, syncope or hypotension, and gastrointestinal symptoms. Idiopathic anaphylaxis-angioedema consists of massive tongue enlargement or severe pharyngeal or laryngeal swelling with urticaria or peripheral angioedema. The differential diagnosis of idiopathic anaphylaxis is reviewed, and treatment approaches are presented.

PMID: 17493503 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Prednisone (Prednisone Intensol® , Sterapred® , Sterapred® DS)

    Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednis...

  • Source: AHFS Consumer Medication Information

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