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1: J Am Vet Med Assoc. 1991 Oct 15;199(8):1057-9.Links

Osteogenic sarcoma and cisplatin chemotherapy in dogs: 16 cases (1986-1989).

Kraegel SA, Madewell BR, Simonson E, Gregory CR.

Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.

Sixteen dogs, given adjuvant cisplatin chemotherapy after amputation for osteogenic sarcoma of the appendicular skeleton, had a median survival time of 413 days. Ten dogs (62%) were alive 1 year after amputation. Dogs were given cisplatin at a dosage of 50 mg/m2 of body surface every 4 weeks for a total of 6 cisplatin treatments, or until metastatic disease was detected. Cisplatin chemotherapy was well-tolerated by most dogs, with only 1 dog developing serious gastrointestinal toxicosis, requiring hospitalization. Results of this study support other investigators' findings that when a cisplatin chemotherapy-based protocol is administered, survival times after amputation can be prolonged for dogs with osteogenic sarcoma.

PMID: 1748612 [PubMed - indexed for MEDLINE]

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