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1: Nat Neurosci. 2007 Jun;10(6):682-4. Epub 2007 May 7.Click here to read Links

Experience-dependent rescaling of entorhinal grids.

Barry C, Hayman R, Burgess N, Jeffery KJ.

Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK.

The firing pattern of entorhinal 'grid cells' is thought to provide an intrinsic metric for space. We report a strong experience-dependent environmental influence: the spatial scales of the grids (which are aligned and have fixed relative sizes within each animal) vary parametrically with changes to a familiar environment's size and shape. Thus grid scale reflects an interaction between intrinsic, path-integrative calculation of location and learned associations to the external environment.

PMID: 17486102 [PubMed - indexed for MEDLINE]