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1: Annu Rev Microbiol. 2007;61:131-48.Click here to read Links

Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.

Tamayo R, Pratt JT, Camilli A.

Howard Hughes Medical Institute, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. rita.tamayo@tufts.edu

Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.

PMID: 17480182 [PubMed - indexed for MEDLINE]