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Pflugers Arch. 2007 Oct;455(1):157-68. Epub 2007 May 4.

Regulation of transient receptor potential (TRP) channels by phosphoinositides.

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  • 1Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, 07103, USA. tibor.rohacs@umdnj.edu

Abstract

This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP(2)) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic.

PMID:
17479281
[PubMed - indexed for MEDLINE]
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