Nat Rev Immunol. 2007 Jun;7(6):479-85.

Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.

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Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA. leslie.berg@umassmed.edu

Abstract

Recent data from three laboratories have identified the TEC kinases, ITK and RLK, as crucial regulators of CD8(+) T-cell development into the conventional lymphocyte lineage. In the absence of ITK and RLK, CD4(+)CD8(+) thymocytes upregulate the T-box transcription factor eomesodermin, and develop into mature CD8(+) T cells that resemble memory cells, exhibit immediate effector cytokine production and depend on IL-15. Furthermore, the selection of these non-conventional 'innate' T cells results from interactions with haematopoietic cells in the thymus. These findings lead to the hypothesis that altered TCR signalling, together with distinct co-stimulatory signals, is the basis for the development of non-conventional T-cell lineages.

PMID:: 17479128; [PubMed - indexed for MEDLINE]

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Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. [Immunity. 2006]
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