Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Immunol. 2007 May 15;178(10):6033-7.

Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria.

Author information

  • 1Queensland Institute of Medical Research, Herston, Australia.

Abstract

Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection, causing significant morbidity and mortality among young children and nonimmune adults in the developing world. Although previous work on experimental CM has identified T cells as key mediators of pathology, the APCs and subsets therein required to initiate immunopathology remain unknown. In this study, we show that conventional dendritic cells but not plasmacytoid dendritic cells are required for the induction of malaria parasite-specific CD4+ T cell responses and subsequent experimental CM. These data have important implications for the development of malaria vaccines and the therapeutic management of CM.

PMID:
17475826
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk