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    Biochem Biophys Res Commun. 2007 Jun 22;358(1):66-72. Epub 2007 Apr 24.

    PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.

    Zhu Z, He X, Johnson C, Stoops J, Eaker AE, Stoffer DS, Bell A, Zarnegar R, DeFrances MC.

    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

    Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator.

    PMID: 17475214 [PubMed - indexed for MEDLINE]

    PMCID: 1978172

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