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Biochem Biophys Res Commun. 2007 Jun 22;358(1):66-72. Epub 2007 Apr 24.

PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.

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  • 1Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.


Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator.

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