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1: Genome Biol. 2007;8(5):R68.Click here to read Click here to read Links

ngLOC: an n-gram-based Bayesian method for estimating the subcellular proteomes of eukaryotes.

King BR, Guda C.

Department of Computer Science, State University of New York at Albany, Washington Ave, Albany, New York 12222, USA. bking@cs.albany.edu

We present a method called ngLOC, an n-gram-based Bayesian classifier that predicts the localization of a protein sequence over ten distinct subcellular organelles. A tenfold cross-validation result shows an accuracy of 89% for sequences localized to a single organelle, and 82% for those localized to multiple organelles. An enhanced version of ngLOC was developed to estimate the subcellular proteomes of eight eukaryotic organisms: yeast, nematode, fruitfly, mosquito, zebrafish, chicken, mouse, and human.

PMID: 17472741 [PubMed - indexed for MEDLINE]

PMCID: PMC1929137