The Broad Institute of Harvard & MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA.
The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.