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Ned Tijdschr Geneeskd. 2007 Apr 14;151(15):856-61.

[Narcolepsy: a new perspective on diagnosis and treatment].

[Article in Dutch]

Author information

  • 1Leids Universitair Medisch Centrum, afd. Neurologie en Klinische Neurofysiologie, Postbus 9600, 2300 RC Leiden.

Erratum in

  • Ned Tijdschr Geneeskd. 2007 Jun 2;151(22):1260.

Abstract

The 5 classic symptoms of narcolepsy are excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep. The presence of cataplexy is strongly associated with a deficiency of the neuropeptide hypocretin. This discovery has led to new diagnostic subclassifications: narcolepsy without cataplexy, which can be demonstrated by a multiple sleep latency test, and narcolepsy with cataplexy, which can be confirmed with a multiple sleep latency test or a cerebrospinal fluid deficiency of hypocretin I. Various treatment options are available, including psychostimulants and gamma hydroxybuterate.

PMID:
17472116
[PubMed - indexed for MEDLINE]
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