Cell Cycle. 2007 May 2;6(9):1019-23. Epub 2007 May 1.

New roads to FA/BRCA pathway: H2AX.

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Group of Mutagenesis, Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

Abstract

We have recently described an involvement of H2AX into the Fanconi anemia (FA) BRCA pathway through recruitment of FA protein FANCD2 to the sites of stalled replication forks. We showed that BRCA1 mediates the recruitment of FANCD2 by gammaH2AX to damaged chromatin and cells deficient or depleted of H2AX exhibit an FA-like phenotype, including an excess of chromatid-type chromosomal aberrations and hypersensitivity to MMC. Here, we discuss a model for the FA pathway and how it could partially explain the common phenotypes of H2AX, BRCA2 and FA deficiencies.

PMID:: 17471025; [PubMed - indexed for MEDLINE]

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Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. [EMBO J. 2007]
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