Br J Exp Pathol. 1975 Oct;56(5):412-22.

The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.

Abstract

Male rats have a greater microsomal amidopyrine N-demethylase activity per unit weight of liver, a shorter hexobarbitone sleeping time and are more susceptible to the hepatotoxic effect of chloroform than female rats. Phenobarbitone sodium, phenylbutazone and DDT induce microsomal amidopyrine N-demethylase in the liver of the male rat and reduce hexobarbitone sleeping time. Chlorpromazine is less effective in this respect. Phenobarbitone, phenylbutazone and, to a lesser extent, chlorpromazine potentiate the hepatotoxic effect of chloroform in male rats. SKF 525A, sodium diethyl-dithiocarbamate and carbon disulphide increase hexabarbitone sleeping time in male rats and protect to varying degrees against the hepatotoxic effect of chloroform.

PMID:: 174709; [PubMed - indexed for MEDLINE]
PMCID:: PMC2072781

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse. [J Pathol. 1976]
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Gopinath G, Ford EJ. J Pathol. 1976 Jun; 119(2):105-12.
Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents. [Biochem Pharmacol. 1982]
Protective effect of diethyldithiocarbamate and carbon disulfide against liver injury induced by various hepatotoxic agents.
Masuda Y, Nakayama N. Biochem Pharmacol. 1982 Sep 1; 31(17):2713-25.
Effect of repeated exposure to aniline, nitrobenzene, and benzene on liver microsomal metabolism in the rat. [Br J Ind Med. 1975]
Effect of repeated exposure to aniline, nitrobenzene, and benzene on liver microsomal metabolism in the rat.
Wiśniewska-Knypl JM, Jablońska JK, Piotrowski JK. Br J Ind Med. 1975 Feb; 32(1):42-8.
Review Factors influencing steroid hydroxylases in liver microsomes. [Adv Enzyme Regul. 1966]
Review Factors influencing steroid hydroxylases in liver microsomes.
Kuntzman R, Welch R, Conney AH. Adv Enzyme Regul. 1966; 4:149-60.
Review Sex-related differences in drug metabolism. [Drug Metab Rev. 1974]
Review Sex-related differences in drug metabolism.
Kato R. Drug Metab Rev. 1974; 3(1):1-32.

See reviews... See all...

Cited by 1 PubMed Central article

Toxic interactions among environmental pollutants: corroborating laboratory observations with human experience. [Environ Health Perspect. 1994]
Toxic interactions among environmental pollutants: corroborating laboratory observations with human experience.
Krishnan K, Brodeur J. Environ Health Perspect. 1994 Nov; 102 Suppl 9:11-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of microsomal hydroxylases in the modification of chloroform hepatotoxi...
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Br J Exp Pathol. 1975 Oct ;56(5):412-22.

PubMed
Assisted reproductive technology in Europe, 2003. Results generated from Europea...
Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE.
Hum Reprod. 2007 Jun ;22(6):1513-25. Epub 2007 Apr 30 .

PubMed
We should desist using RECIST, at least in GIST.
We should desist using RECIST, at least in GIST.
J Clin Oncol. 2007 May 1 ;25(13):1760-4.

PubMed
Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinote...
Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest.
J Clin Oncol. 2007 May 1 ;25(13):1670-6.

PubMed
Open-label phase III trial of panitumumab plus best supportive care compared wit...
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer.
J Clin Oncol. 2007 May 1 ;25(13):1658-64.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information