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Antimicrob Agents Chemother. 2007 Jul;51(7):2615-7. Epub 2007 Apr 30.

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.

Author information

  • 1Infectious Disease Service, MCHE-MDI, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. matthew.griffith@amedd.army.mil

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

PMID:
17470646
[PubMed - indexed for MEDLINE]
PMCID:
PMC1913230
Free PMC Article
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