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Am J Health Syst Pharm. 2007 May 1;64(9 Suppl 5):S15-24.

Oral chemotherapeutic agents: understanding mechanisms of action and drug interactions.

Author information

  • University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08901, USA. goodin@umdnj.edu

Abstract

PURPOSE:

The mechanisms of action and drug interactions of oral chemotherapeutic agents are reviewed.

SUMMARY:

The mechanisms of action, indications, and potential for drug interactions vary for oral chemotherapy. Traditional oral chemotherapy agents cause damage to cancer cells by non-specifically interfering with cellular division. Many of the newer agents have novel targets on cancer cells preferentially, resulting in a different spectrum of toxicity. Since cancer patients are at high risk for drug interactions, usually because of age-related organ dysfunction and the need for concomitant drug therapy for comorbid conditions, understanding these agents and potential for interactions is imperative for all healthcare providers.

CONCLUSION:

Knowledge of the mechanisms and metabolic pathways for the oral chemotherapeutic agents allows the potential to predict possible drug interactions and response while minimizing the risk of adverse outcomes.

PMID:
17468152
[PubMed - indexed for MEDLINE]
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